CBD (Cannabidiol) and THC (tetrahydrocannabinol) share a special interdependent relationship and work together to increase one another’s therapeutic benefits. CBD is a non-psychoactive compound. THC is psychoactive and, therefore, may produce euphoric or dysphoric effects. A patient’s sensitivity to THC is a key factor in determining appropriate dosage and ratios for a CBD-rich treatment regimen. CBD can lessen or neutralize the psychoactivity of THC. So an increased ratio of CBD-to-THC means fewer mental effects.
Cannabis therapeutics is personalized medicine. The appropriate dosage depends upon the person and condition being treated.
NOTE: Most animal studies with cannabidiol utilize synthetic, single-molecule CBD produced by biochemical laboratories for research purposes. In contrast, whole plant extractions typically include THC and more than 400 trace compounds. These other compounds interact synergistically to create an “entourage effect” that can magnify the therapeutic benefits of the individual components. It is important to consider the entourage effect (or lack thereof) when extrapolating data based on animal studies: 100 milligramsof synthetic CBD is not equivalent to 100 milligrams of a CBD-rich whole plant cannabis extract. One should not assume that data from animal studies is necessarily applicable for cannabis patients.